pregnancy test april fools day 2012 ja rule amityville horror acm passover recipes 2012 kids choice awards
সোমবার, ২৯ এপ্রিল, ২০১৩
S&P 500 ends at record high on growth stocks
NEW YORK (Reuters) - Stocks extended a rally on Monday, with the S&P 500 unofficially ending at an all-time high as growth-oriented stocks like energy and technology lead the way.
Based on the latest available data, the Dow Jones industrial average <.dji> was up 105.21 points, or 0.72 percent, at 14,817.76. The Standard & Poor's 500 Index <.spx> was up 11.29 points, or 0.71 percent, at 1,593.53, surpassing the previous record of 1,593.37. The Nasdaq Composite Index <.ixic> was up 27.76 points, or 0.85 percent, at 3,307.02.
(Reporting By Caroline Valetkevitch; Editing by Kenneth Barry)
Source: http://news.yahoo.com/stock-futures-higher-ahead-data-corporate-results-115148731.html
social security social security paulina gretzky paulina gretzky david bowie elvis presley elvis presley
Thymus teaches immune cells to ignore vital gut bacteria
Apr. 29, 2013 ? The tiny thymus teaches the immune system to ignore the teeming, foreign bacteria in the gut that helps you digest and absorb food, researchers say.
When immune cells recognize essential gut bacteria as foreign, inflammatory bowel disease such as ulcerative colitis and Crohn's disease can be the painful, debilitating result.
In a study published in the journal Nature, researchers show that the regulatory T cells, or Tregs, that keep this from happening in most of us come from the tiny immune organ nestled near the heart, said Dr. Leszek Ignatowicz, immunologist in the Center for Biotechnology and Genomic Medicine at the Medical College of Georgia at Georgia Regents University.
In fact, mice born lacking T cells that were given a specific T cell type that causes colitis-like wasting disease, didn't get the disease if they also received thymus-derived Tregs.
"This essential gut-bacteria is one group that you don't want to mount an immune response against," said Ignatowicz, the study's corresponding author. "In fact, you need the Tregs' help in inducing tolerance to these bacteria if you want to treat Crohn's and other inflammatory bowel disease."
Knowing exactly where the Tregs come from is essential to making more of them, noted Dr. Richard A. McIndoe, the center's Associate Director and a study co-author. "The Tregs have to shut down the immune response. The question is: Do we have to expand the pre-existing Tregs that came to the gut from the thymus or teach peripheral na?ve or effector T cells to become Tregs? "
The answer was thought to be that most immune cells learn to ignore the vital bacteria after they reach the gut. However, the new study shows that only a fraction of bacteria-friendly Tregs come from there. Since T cells don't have license plates, they looked at their antigen receptors and found the Tregs in the gut had the same receptors as their precursors in the thymus. Easing the comparison was the fact that na?ve T cells, which also get their education in the thymus, have mostly different receptors than thymus-educated Tregs.
They soon realized that while conversion of na?ve cells to Tregs occurs more often in the gut than other organs, it was much less frequent than conventionally believed. Once in the gut, na?ve cells can become Tregs or effector cells; effector cells only attack unless constrained by Tregs.
"We either have to induce effector T cells to change to Tregs or boost the number of Tregs coming out of the thymus to help patients with inflammatory bowel disease," McIndoe said. Some compounds, including vitamin A and transforming growth factor beta, already are known to aid conversion.
While T-cells mostly earn their receptors in the thymus, most don't take action until they actually see their chosen antigens, a variety of substances that can provoke an immune response. Well-educated thymus-derived Tregs can recognize antigens from the body's tissue as well as foreign antigens derived from sources like gut bacteria. Interestingly most immune cells circulating in the body are na?ve T-cells that become effector cells upon their first contact with an antigen.
It was previously believed that thymus-derived Tregs primarily protect the body's own tissue but don't induce tolerance to foreign antigens like ones derived from gut's bacteria. However Ignatowicz and Dr. Rafal Pacholczyk reported in 2007 in the journal Immunity that Tregs could actually recognize both self- and non-self-antigens. The gut, which regularly deals with an onslaught of foreign substances such as food and drink, was a logical place to figure out where the accommodating Tregs originated, Ignatowicz said.
MCG scientists note that effector cells also are needed in the gut to recognize and eliminate harmful bacteria, such as campylobacter, a common cause of diarrhea, vomiting and abdominal cramping that can result from eating inadequately washed and cooked poultry.
Populating gut bacteria starts early, with mother's milk or formula, and is determined largely by diet as well as the environment so every individual's is different although bacteria tend to be compatible among the same species, McIndoe said.
Vaccines are likely the oldest example of using the body's natural defense system to protect against invaders. Conversely, select immune cell populations already are being used to help fight cancer. More sophisticated approaches are being developed to turn down the immune response, in the case of an organ transplant or an autoimmune disease such as lupus or arthritis.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by Medical College of Georgia at Georgia Regents University, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Anna Cebula, Michal Seweryn, Grzegorz A. Rempala, Simarjot Singh Pabla, Richard A. McIndoe, Timothy L. Denning, Lynn Bry, Piotr Kraj, Pawel Kisielow, Leszek Ignatowicz. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature, 2013; DOI: 10.1038/nature12079
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/TDQLYj2_2lA/130429130512.htm
daniel day lewis Life of Pi Christoph Waltz Quvenzhané Wallis dancing with the stars cast kristen stewart Shirley Bassey
JPMorgan co-COO Bisignano leaves to run First Data
NEW YORK (AP) ? JPMorgan Chase & Co. said Sunday that one of its co-chief operating officers is leaving the company, marking the latest high-profile departure since the bank's massive trading loss last year.
Frank Bisignano will become CEO of payment processor First Data Corp. on Monday. Matt Zames, who was co-chief operating officer with Bisignano, will become the sole COO of JPMorgan Chase effective immediately.
First Data said Bisignano, 53, succeeds Ed Labry, who has been interim CEO and president of Retail and Alliance Services since Jan. 28. Labry will continue as president of Retail and Alliance Services.
Bisignano and Zames were named co-chief operating officers in a management reshuffle in July after JPMorgan Chase revealed a trading loss of about $6 billion. The massive loss became a focus of the risky bets taken at large banks and oversight of traders who make those bets. It also prompted congressional hearings, as well as investigations by international regulators.
Others called for the resignation of CEO Jamie Dimon, who initially called the trade a "tempest in a teapot." Dimon later backtracked and apologized several times for the mischaracterization after the scope of the loss was revealed.
The Wall Street Journal first reported that Bisignano would be the ninth executive in the past year and a half to leave Dimon's operating committee of key decision makers.
Dimon and Bisignano have known each other since the 1980s, according to the Journal, and worked together at Citibank.
Before he was named co-chief operating officer this summer, Zames had taken over as chief investment officer for Ina Drew, who resigned in the days after the big trading loss was revealed.
JPMorgan also said Sunday that Paul Compton will become chief administrative officer. He is currently co-chief administrative officer of the Corporate & Investment Bank and deputy head of operations for JPMorgan Chase.
Louis Rauchenberger, who shares Compton's current role, will become sole chief administrative officer of the Corporate and Investment Bank.
Associated Pressillinois primary trayvon martin 911 call kiribati vernal equinox mr rogers jamie lee curtis spring equinox
Curry leads Warriors past Denver 115-101 in Game 4
OAKLAND, Calif. (AP) ? Stephen Curry shook off a sore left ankle to score 22 of his 31 points in the third quarter, leading the Golden State Warriors past the Denver Nuggets 115-101 on Sunday night for a commanding 3-1 series lead.
Curry shot 10 of 16 from the floor and added seven assists in a dominant and dazzling display that rivaled his days in the NCAA tournament for tiny Davidson. His five 3-pointers in the third quarter lifted Golden State to a 20-point lead and its third straight victory in this frenetic and flashy series.
Jarrett Jack added 21 points and nine assists and Andrew Bogut broke out in the first half with 12 points and five rebounds for the sixth-seeded Warriors, who can close out the Nuggets in Game 5 on Tuesday night in Denver.
Ty Lawson scored 26 points and Andre Iguodala had 19 for the third-seeded Nuggets.
The Warriors lost All-Star forward David Lee to a season-ending hip injury in Game 1, and Curry sprained his left ankle late in Game 2. With Curry carrying the load anyway, none of it has seemed to matter.
The quick-shooting point guard hit 5 of 8 from beyond the arc in a spectacular third quarter, when nearly every gold-shirt wearing fan in the sellout crowd of 19,596 stood and cheered. Curry scored all 22 points in the final 6:22 of the quarter, showing the kind of range that helped him make 272 3-pointers in the regular season ? three more than Ray Allen's record set in 2005-06 with Seattle.
Curry capped his remarkable run with two of his most highlight-reel plays.
He stole the ball from Lawson, stopped in heavy traffic and dropped in a 27-footer before sprinting all the way to the bench high-fiving and chest-bumping teammates. Following a timeout, Curry sprung free near Denver's bench for a corner 3 that gave Golden State a 91-72 lead entering the fourth.
Curry's five 3s in the quarter were a Warriors record for a half.
Curry, wearing heavy tape around his nagging ankle, gave fans a scare when Corey Brewer poked Curry in the eye going for a rebound early in the fourth. Curry returned about 4? minutes later, receiving another standing ovation from the home fans.
While Curry scored only seven points in the first half, Bogut broke out in a big way to provide the one-two punch Golden State had long envisioned.
The 7-footer from Australia sliced down a wide open lane off a pick-and-roll with Curry in the first quarter, took one dribble and dunked over JaVale McGee with a thunderous right-handed slam. Bogut, who received a technical foul in Game 3 for daring Denver's big man to punch him on the chin during a face-to-face altercation, stared back at McGee while backpedalling down court.
In the second quarter, Bogut backed down Kosta Koufos before hammering home another dunk. He also soared high for a backdoor alley-oop from Curry to help the Warriors go ahead 45-37, and chants of "Bogut! Bogut!" echoed around the arena while the video board kept replaying his dunks.
Bogut sat out the final 4:37 of the first half with three fouls, and Andre Miller almost single-handily brought Denver back within a point. Then Curry hit his first 3-pointer of the game ? officially a 27-footer that seemed closer to the scorer's table than the arc ? as Golden State scored the last 11 points before the break to go ahead 56-44.
After falling behind by 15 early in the third quarter, the Nuggets started to rally behind their point guard.
Lawson, who scored a career-playoff high 35 points in the Game 3 loss, shook off a slow start to highlight a 14-4 run that sliced Golden State's lead to 62-58 midway through the third quarter. Just when it seemed they might crawl back, Curry countered with a devastating blow to Denver's playoff hopes.
NOTES: For the third straight game, Warriors coach Mark Jackson listed Carl Landry at power forward in his starting lineup submitted before the game, even though Harrison Barnes started at power forward and Landry came off the bench. Jackson said beforehand that he'd do it again because "it worked." Nuggets coach George Karl said it's not what coaches typically do but joked that Jackson is "consistent" and maybe "superstitious." ... Jackson's wife, Desiree Coleman Jackson, sang the national anthem.
Source: http://news.yahoo.com/curry-leads-warriors-past-denver-115-101-game-042746068.html
tomb of the unknown soldier tomb of the unknown soldier HMS Bounty dominion power Heather Clem Con Edison LaGuardia Airport
রবিবার, ২৮ এপ্রিল, ২০১৩
Uncover gives your MacBook's lid a new, Apple-less kind of glow
Etsy stickers adorning your MacBook's lid, oft making a cute play on the presence of that glowing Apple? That's so 2012. Uncover, a Dutch company showcasing its talents here at The Next Web Conference in Amsterdam this week, has crafted a new method of customizing one's MacBook lid. And, perhaps most importantly, it involves the seamless removal of the Apple logo altogether. In essence, these guys use a specialized laser cutting process that can etch out anything your brain can muster -- from band logos to company mantras. And, as you'll see in the gallery below, the Apple logo doesn't have to be a part of the equation.
The outfit will take in any aluminum-faced MacBook from around the world, and once it lands in Holland, you'll typically see it headed back to your domicile within four to five days. If you're selecting one of Uncover's designs, you can have your machine tweaked for as little as €249 (around $325), while completely custom work starts at €599 ($780). (And yes, you can just buy a totally new Mac from Uncover as well.) We spoke to Jasper Middendorp, the company's CEO, and he confessed that only MacBooks are being accepted due to Apple's unique backlighting arrangement. They're obviously keen to offer similar work for PCs, but to date, every one he has seen blocks or covers the backlight in some way. For those looking to get it on the fun, allow the source link below to be your guide.
Filed under: Laptops
Source: Uncover
ricky martin larry bird chauncey billups caucus results exton kurt warner kurt warner
New excavations in Sweden indicate use of fertilizers 5,000 years ago
Apr. 26, 2013 ? Researchers from the University of Gothenburg, Sweden, have spent many years studying the remains of a Stone Age community in Karleby outside the town of Falk?ping, Sweden. The researchers have for example tried to identify parts of the inhabitants' diet. Right now they are looking for evidence that fertilisers were used already during the Scandinavian Stone Age, and the results of their first analyses may be exactly what they are looking for.
Using remains of grains and other plants and some highly advanced analysis techniques, the two researchers and archaeologists Tony Axelsson and Karl-G?ran Sj?gren have been able to identify parts of the diet of their Stone Age ancestors.
'Our first task was to find so-called macrofossils, such as old weed seeds or pieces of grain. By analysing macrofossils, we can learn a lot about Stone Age farming and how important farming was in relation to livestock ranching,' says Axelsson.
Another aim has been to collect animal bone material -- or simply 5,000 year old food remains. The researchers know that pieces of bones from cattle, pigs and sheep can be found at the site.
'By studying the levels of isotopes in the bones, we can for example find out where the animals were raised, which in turn can give important information about their role in trade,' says Sj?gren.
The results of the first grain analyses have now been presented, and besides revealing that both barley and wheat were farmed at the site, they point to elevated levels of the isotope N15 (nitrogen 15). The elevated levels may indicate that fertilisers were used in the area of Karleby already 5,000 years ago.
'We will continue our analyses both in the field and in the lab, and are hoping to find more macrofossils. Hopefully we'll find some weed seeds, as they may help confirm that fertilisers were indeed used since the type of weeds found in a field can signal whether fertilisers or some other method was used,' says Axelsson.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by University of Gothenburg.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
is snooki pregnant snooki pregnant gbc hedy lamarr kowloon walled city ronda rousey vs miesha tate lindsay lohan snl
এতে সদস্যতা:
পোস্টগুলি (Atom)